Posts by serentripity

I love to write about poetry, comedy, marketing, technology, evolutionary biology.

Neosporosis: The Closest Thing to a Cure Your Vet Doesn’t Know About

My beautiful Shepherd/Husky mix was diagnosed with Neosporosis, a Protozoan infection that causes a dog to slowly lose power and control over their hind legs, and eventually their front legs and from there it is a very sad slow death.  The experience is obviously difficult for the dog, but it’s also very painful for the owner.

I have a solid background in molecular biology, and currently I develop and market immunotherapies for the veterinary market (see our cancer treatment we are just bringing to the vet market now).  So when several vets told me that there are no effective treatments for dogs in the late stages of infection (showing signs of neurological degeneration), I took it as a challenge to either develop a treatment or to find one.

Let’s jump to my findings: I found an academic review of all the drugs in the experimental pipeline (difficult to read, but invaluable). Of all the drugs discussed, three caught my attention:

  1. Guanabenz
  2. Miltefosine
  3. “Compound 32”

It’s About Brain Cysts

The reason why prognosis is grim with conventional meds is because Neospora eventually forms cysts in the infected host.  Once cysts are formed, neither the immune system nor conventional drugs have efficacy.  That’s why there are cases where a dog gets diagnosed soon after being infected, gets antibiotics, and is cured.  This is rare, but it goes to show how important it is to diagnose and treat the infection before it gets to the cyst state.

The three drugs above all cross the blood brain barrier and reduced the number of brain cysts.  Of the three drugs, only Guanabenz and Miltefosine are FDA approved and available.

I went to my primary vet a few days ago and begged for a prescription for either Guanabenz or Miltefosine.  My vet didn’t want to risk his license prescribing drugs not FDA approved for Neosporosis, which I can understand.  Even if he had given me a prescription, it turns out the cost for these medications in the US is obscene: one month of Miltefosine would be $32,000.  Guanabenz is about the same.

I leveraged overseas contacts in biotech, and was able to find Miltefosine (my first choice) for an affordable price.  I should receive the medication in about ten days, and I’ll update this blog with results after we’ve started treatment.  I am very anxious and eager to receive it, as Oscar cannot walk and everyday I worry about what function or comfort he will lose next.  I love this dog so much and it’s just tearing me apart watching this infection progress.

If you have a dog with Neosporosis, and you have questions or comments, feel free to use the form below.  If I can help a dog in need, I will!

There is a great support group on Facebook for owners of dogs with Neosporosis.

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“Make America Great Again” the Low Outputs Say.

It’s Hard to Make America More Great When Trump Supporters Don’t Do Shit

Brookings Institute finds Trump supporters are the lowest output workers, BY FAR, in the country.  And don’t ask about their IQ’s.

screenshot-www-google-com-2017-02-05-17-11-21This is funny, but sadly it’s not a joke.

The Brookings Institute found Trump Supporters are the GDP dregs.

“The less-than-500 counties that Hillary Clinton carried nationwide encompassed a massive 64 percent of America’s economic activity as measured by total output in 2015.  By contrast, the more-than-2,600 counties that Donald Trump won generated just 36 percent of the country’s output—just a little more than one-third of the nation’s economic activity.”

I realized a few months before the election that Trump would win.  It hit me while I was arguing that Trump would never win, and my reasoning was that Americans could never be so stupid as to vote for this clown.  That was my “OH SHIT” moment, I knew we were fucked right then.

WIDESPREAD DEFECTS, AVOID IPV 5 Vaporizer by Pioneer4you

ipv5-vaporizer-check-battery-error-defectINTRO
This is a review of the IPV 5 vaporizer mod by Pioneer4you (Chinese company). This would be a great product if it weren’t for a known defect that the company is basically ignoring unless (from what I have heard) you keep pushing them, at which point you’ll just get a replacement which is going to have the same problem.  This defect affects the series, not just one model, according to the forums you can check by searching Google with queries like this one. Avoid all IPV series by Pioneer

THE “CHECK BATTERY” IPV MALFUNCTION ERROR

I’m not going into details about the malfunction, as you can find the real vape nerds discussing this in many forums, but basically a “CHECK BATTERY” message will come on and the device will not hit.  This will happen when batteries are charged.  You can even have the device plugged into an outlet and it happens.

HIGH RISK of MISSING RETURN POLICY WINDOW

WHY? IPV 5 is Complicated, Must STUDY Owner Manual

Dispute Purchase with Credit Card Company if Possible, Don’t Give eBay, Paypal Total Control

EBAY SELLER POWERPUH IS IGNORING REQUESTS FOR RETURN

It took me two weeks to be able to fire the device up because of the huge learning curve to operate the menu.  This is another problem with this device…it is NOT SIMPLE.  You MUST not just read, but actually STUDY the owners manual to use it.  By the time I was using it, the 30 days for return policy was expiring.  I got the CHECK BATTERY message on day two … after that it was ever few hours.  I have sets of charged batteries that are good.  Too many people have this problem for it to be your fault.  Anyway, so this POWERPUH

 

screenshot-mesg-ebay-com-2017-02-18-13-59-12

TAKE-AWAY ADVICE: BUY REPUTABLE OR ASK ABOUT REFUND (not return for replacement) POLICY

and don’t buy from eBay seller POWERPUH, he ignores return requests:

powerpuh-negative-reviews

Frontier Tech Ventures Engages Craig Hordlow for Marketing and Communications

SAN FRANCISCO – Feb. 7, 2017 – PRLog — Frontier Tech Ventures (FTV), a venture capital firm, has attracted Craig Hordlow, previously co-founder of Red Bricks Media, to lead its marketing and communications. Hordlow is a marketing strategy thought leader, having created and managed marketing and communications strategies for many big brands, including Adobe Systems, American Express, Conde Nast, and Hearst. Hordlow has also presented cutting edge strategies at major conferences such as Web 2.0, Adobe MAX, O’Reilly, and Search Engine Strategies.

“Frontier Tech Ventures (fka Rothenberg Ventures) is excited to have such a smart, experienced professional come on board now,” said Founder and CEO Mike Rothenberg. “Now that we’re at a point where our funds are top-performing and we’re receiving recognition from groups like Goldman Sachs, it’s time for our communication strategy to climb to the same A-level as our investment work.”

“People who have worked with me know how excited I get bringing a great product to market,” Hordlow said. “And here we’ve got a young company with a truly stunning track record, topping Goldman Sachs and other analysts’ lists, but the press doesn’t appreciate how successful FTV has become. I’m going to fix that.”
Frontier Tech
Read the full press release about Craig Hordlow’s Frontier Tech Ventures role

The Bogmen Release New Single

The Bogmen Come Back Swinging

One of the best bands to ever come out of New York City, The Bogmen are back with another great song.

When The Circus Comes to Town

When the Circus Comes to Down (wav, 53 megs)


Other Music to Check Out

Chris O’Connor

I was the “anti-producer” on this album – I did nothing other than make sure the recording was as bare bones as possible. Great lyrics, fantastic vocalist.

  • You Are Here

    My Music

    Here are three songs I wrote and sing (scroll down the page for lyrics):

    Erogenous Jones, Music by Craig Hordlow

    1. Tube Sock Toes (wav)
    2. Big Time (wav)
    3. The Al Franken Song (wav)

    Tube Sock Toes

    Verse 1
    She wiggles her toes when she cums,
    She wiggles her toes, her tube-sock toes.
    And she screams my name through the walls,
    She screams my name, screams through the walls.
    And she freaks me out when she cums,
    She freaks me out, and that’s what this song is about.

    Chorus
    Well I’m singing these songs so I can say anything I fucking want to.
    I’ve got the first word, and the last one too,
    it’s about you, and there’s nothing you can do.
    Better be careful of the things that you do,
    You piss us off, we’ll be singing about you.

    Verse 2
    She likes her nipples squeezed, her nipples squeezed,
    Squeezed when she cums.
    And all the neighbors know my name, they know my name
    Because it’s screamed through the walls.
    And if she hears me sing this song, she’ll rip off my head
    And shit down my neck.

    Chorus
    Well I’m singing these songs so I can say anything I fucking want to.
    I’ve got the first word, and the last one too,
    it’s about you, and there’s nothing you can do.
    Better be careful of the things that you do,
    You piss us off, we’ll be singing about you.

    Bridge:
    I like singing these songs, of people who’ve done me wrong.
    Another “somebody’s done somebody wrong song”,
    Somebody’s done somebody wrong

    Verse 3
    She gyrates her hips when she cums, she gyrates her hips
    So the G-Spot gets hit.
    I grab her neck when she cums, asphyxiation gives her elation
    And she breaks the damn when she cums, then she sits on my head
    And tells me to say, “Ah”

    Chorus
    Well I’m singing these songs so I can say anything I fucking want to.
    I’ve got the first word, and the last one too,
    it’s about you, and there’s nothing you can do.
    Better be careful of the things that you do,
    You piss us off, we’ll be singing about you.

    Chorus Out
    Somebody’s done somebody wrong song
    A somebody’s done somebody wrong
    Somebody’s done somebody wrong song
    A somebody’s done somebody wrong

    Big Time

    Big Time

    Verse 1
    Hookers and cocaine,
    Hookers and cocaine,
    Hookers and cocaine,
    Hookers and cocaine,

    Chorus
    When we make it big time,
    Have a good time, have a really good time,
    Have a good time, have a really good time.

    Verse 2
    We’ll find the drug Huey Lewis was looking for,
    We’ll find the drug Huey Lewis was…

    Chorus
    When we make it big time,
    Have a good time, have a really good time,
    Have a good time, have a really good time.

    Bridge
    Do you think you want to marry me?
    Despite my chronic infidelity.
    Do you think you want to be my wife?
    As I explode into my big time life.

    Bridge 2
    Life, Life, Life

    Chorus
    When we make it big time,
    Have a good time, have a really good time,
    Have a good time, have a really good time.

    Verse 3
    If the party never ends, you’re never hung over.
    Party never ends, you’re never hung.

    Chorus
    When we make it big time,
    Have a good time, have a really good time,
    Have a good time, have a really good time.

    The Al Franken Song

    Verse 1
    Now Al Franken is standing next to you at the urinal, what will you do?
    You’d like to meet him because he’s such a like mind,
    But this is such a strange situation.

    Bridge
    You’ve got two minutes, to talk to this guy, Well
    Cause in two minutes Al Franken zips up his fly.

    Chorus
    The perfect thing to say, never comes till later
    Then when it’s said, it’s only in your daydreams.

    Verse 2
    All your life there have been so very few
    Who think and create in that strange way you do.
    Now Al Franken might think the same of you,
    But at the urinal bonding is tough to do.

    Bridge
    You’ve got two minutes, to talk to this guy, Well
    Cause in two minutes Al Franken zips up his fly.

    Chorus
    The perfect thing to say, never comes till later
    Then when it’s said, it’s only in your daydreams.

    Verse 3
    Now Al Franken is standing next to you at the urinal, what will you do?
    You’d like to meet him because he’s such a like mind,
    But this is such a strange situation.

    Bridge
    You’ve got two minutes, to talk to this guy, Well
    Cause in two minutes Al Franken zips up his fly.

    Chorus
    The perfect thing to say, never comes till later
    Then when it’s said, it’s only in your daydreams.

  • Facebook Advertising ROI vs. Search & Amazon, 2012 – 2015

    Think Facebook advertising is sexy and want to get in on it?

    I tracked my purchases for the last three years.  How many of them originated with Facebook?  Zero.

    As a marketer and advertiser, I have spent thousands of dollars of my clients’ money on Facebook, Google, Bing, and other channels?

    Which one performs the best?  Well, it depends on the channel.  However, in markets that have the highest CPC that are budget constrained, Bing outperforms other channels regularly.

    Facebook advertising ROI vs. Google, Bing, Amazon and other markets.

    Facebook advertising ROI vs. Google, Bing, Amazon and other markets.